Blog entry by Arlen Mintz
ADHD Medication During Pregnancy and Breastfeeding
The choice of whether to stop or continue ADHD medication during pregnancy and breastfeeding is a challenge for women suffering from the condition. There aren't enough data on how to get adhd medication without diagnosis long-term exposure may affect the foetus.
A recent study published in Molecular Psychiatry demonstrates that children exposed to adhd medication making It worse medication during pregnancy do not develop neurological problems such as hearing loss or vision, febrile seizures, or IQ impairment. The authors acknowledge that more high-quality research is needed.
Risk/Benefit Analysis
Women who are pregnant and taking ADHD medication should consider the benefits of taking it versus the risks to the foetus. Physicians don't have the data to give clear advice, but can provide information about risks and benefits to help pregnant women make informed decisions.
A study published in Molecular Psychiatry found that women who took adhd medications for adults with anxiety medications during early pregnancy did not face an higher risk of fetal cardiac malformations or major structural birth defects. Researchers conducted a large population-based study of case control to examine the prevalence of major structural defects in infants born to mothers who were taking stimulants during pregnancy. Pediatric cardiologists and clinical geneticists reviewed the cases to ensure correct classification of the cases and to reduce the chance of bias.
However, the researchers' study had its limitations. The researchers were unable, in the first place to distinguish the effects of the medication from the disorder. This limitation makes it difficult for researchers to determine if the small differences observed between the groups exposed were due to the use of medication, or if they were confounded by comorbidities. Researchers also did not examine long-term outcomes for the offspring.
The study did show that infants whose mothers had taken ADHD medication during pregnancy were at a slightly more risk of being admitted to the neonatal intensive care unit (NICU) than those whose mothers had not taken any medication or cut back on their medications prior to or during pregnancy. This increase was caused by central nervous system disorders. The higher risk of admission was not affected by the stimulant medication used during pregnancy.
Women who took stimulant ADHD medications during pregnancy also had a higher likelihood of having a caesarean section or a baby that scored low on the Apgar scale (less than 7). These increases didn't appear to be influenced by the kind of medication used during pregnancy.
The research suggests that the risk of a small amount with the use of ADHD medications during the early stages of pregnancy could be offset by the greater benefits to both mother and child from continued treatment for the woman's condition. Physicians should discuss the issue with their patients and, where possible, help them develop strategies to improve coping skills which can reduce the effects of her disorder on her daily life and relationships.
Medication Interactions
More and more doctors are faced with the decision of whether to continue treatment or stop as more women are diagnosed with ADHD. Often, these decisions are taken in the absence of clear and authoritative evidence in either case, which means that doctors must weigh what they know, the experiences of other doctors, and what research says on the topic and their own judgments for each individual patient.
In particular, best over the counter adhd medication for adults issue of possible risks to the infant can be difficult. Many of the studies on this topic are based on observational data instead of controlled research and their findings are often contradictory. Additionally, the majority of studies limit their analysis to live births, which may underestimate the severity of teratogenic effects that could lead to abortion or termination of the pregnancy. The study discussed in the journal club addresses these issues by analyzing both data on live and deceased births.
The conclusion: While certain studies have demonstrated that there is a positive correlation between ADHD medications and the risk of certain birth defects, other studies have found no such relationship and the majority of studies demonstrate a neutral or slightly negative impact. In the end, a careful risk/benefit analysis must be done in each situation.
It isn't easy, but not impossible for women with ADHD to stop taking their medication. In an article published in the Archives of Women's Mental Health, psychologist Jennifer Russell notes that stopping adhd depression medication medication during pregnancy can cause depression, feelings of loneliness and family conflict for those suffering from the disorder. A decrease in medication could affect the ability to drive safely and perform work-related tasks, which are vital aspects of normal life for those suffering from ADHD.
She recommends women who are uncertain about whether to keep or stop medication in light of their pregnancy should consider educating family members, friends and colleagues about the condition, its impact on daily functioning, and the advantages of continuing the current treatment plan. It can also help women feel more confident in her decision. Certain medications can be passed through the placenta. If a patient decides not to take her ADHD medication while pregnant and breastfeeding, it is important to be aware that the medication could be transferred to the infant.
Birth Defects Risk
As the use of ADHD medications to treat symptoms of attention deficit hyperactivity disorder (ADHD) increases as do concerns about the effects that the drugs could have on fetuses. Recent research published in the journal Molecular Psychiatry has added to the body of knowledge on this topic. Researchers used two huge datasets to analyze more than 4.3 million pregnant women and determine if stimulant medication use increased the risk of birth defects. Researchers discovered that, while the overall risk is low, the first trimester ADHD exposure to medication was associated with slightly higher rates of certain heart defects, like ventriculoseptal defect.
The authors of the study didn't discover any connection between early medication usage and other congenital anomalies like facial deformities or club feet. The results are consistent with previous studies that have shown a small but significant increase in the risk of heart malformations among women who began taking ADHD medications prior to the time of pregnancy. The risk increased in the latter stages of pregnancy, when a lot of women stopped taking their medication.
Women who took ADHD medications in the first trimester of their pregnancies were also more likely to undergo a caesarean section, a low Apgar score after delivery and a baby who required breathing assistance at birth. The researchers of the study could not eliminate bias due to selection because they limited their study to women with no other medical conditions that could have contributed to the findings.
Researchers hope their research will help doctors when they meet pregnant women. They suggest that although a discussion of the risks and benefits is crucial but the decision to stop or continue medication must be based on each woman's needs and the severity of her ADHD symptoms.
The authors also warn that while discontinuing the medications is an alternative, it is not an option that is recommended due to the high rate of depression and other mental health issues for women who are expecting or who are recently postpartum. Further, the research suggests that women who choose to stop their medications are more likely to have difficulties getting used to life without them following the birth of their baby.
Nursing
It can be overwhelming becoming a mother. Women who suffer from ADHD are often faced with a number of difficulties when they have to manage their symptoms, go to doctor appointments and prepare for the birth of their child and adjust to a new routine. Many women opt to continue taking their ADHD medication during pregnancy.
The risk to breastfeeding infant is not too high since the majority of stimulant medication is absorbed through breast milk in low amounts. However, the rate of medication exposure to the infant can differ based on dosage, how often it is administered and the time of the day the medication is administered. In addition, individual medications enter the baby's system differently through the gastrointestinal tract as well as breast milk, and the effect of this on a newborn infant is not yet fully understood.
Some doctors may decide to stop stimulant medications during a woman's pregnancy due to the lack of research. This is a difficult choice for the patient, who must weigh the benefits of continuing her medication against the potential dangers to the foetus. Until more information is available, doctors should ask all pregnant patients about their experience with ADHD and if they plan or are taking to take medication during the perinatal period.
A growing number of studies have revealed that the majority of women are able to safely continue their ADHD medication during pregnancy and while breastfeeding. As a result, an increasing number of patients opt to do this, and after consulting with their doctor, they have found that the benefits of continuing their current medication far exceed any risk.
Women with ADHD who are planning to nurse should seek advice from a specialist psychiatrist before becoming pregnant. They should discuss their medication with their prescriber as well as the pros and cons of continuing treatment. This includes non-pharmacological strategies. Psychoeducation is also required to help pregnant people with ADHD recognize their symptoms and the root cause, learn about available treatment options and reinforce existing coping strategies. This should be a multidisciplinary effort together with obstetricians, GPs, and psychiatry. Pregnancy counseling should include discussion of a treatment plan for the mother as well as the child, and monitoring for signs of deterioration and, if necessary modifications to the medication regimen.