Blog entry by Jonelle Whicker
ADHD Medication During Pregnancy and Breastfeeding
The decision to stop or continue ADHD medication during pregnancy and breastfeeding is challenging for women with the condition. There aren't many studies on how does medication for adhd work exposure to ADHD for a long time could affect a pregnant fetus.
A study recently published in Molecular Psychiatry demonstrates that children exposed to adhd no medication medication during pregnancy do not develop neurological issues such as hearing loss or vision, febrile seizures, or IQ impairment. The authors acknowledge that more high quality research is needed.
Risk/Benefit Analysis
Women who are expecting and taking ADHD medication need to evaluate the benefits of using it against the possible risks for the foetus. The doctors don't have the information to provide clear recommendations but they can provide information on the risks and benefits to aid pregnant women in making informed choices.
A study published in Molecular Psychiatry found that women who used ADHD medications during early pregnancy did not face a significantly increased risk of fetal cardiac malformations or major structural birth defects. Researchers used a large sample-based case control study to compare the incidence of structural defects that were major in infants who were born to mothers who used stimulants during pregnancy. Clinical geneticists and pediatric cardiologists examined the cases to ensure correct case classification and to minimize the possibility of bias.
The research conducted by the researchers had some limitations. Researchers were unable, in the first place to distinguish the effects triggered by the medication from the disorder. This limitation makes it difficult for researchers to determine if the small associations observed among the exposed groups were due to the use of medications, or if they were caused by comorbidities. In addition the researchers did not study long-term offspring outcomes.
The study did show that infants whose mothers took adhd medication uk medication during pregnancy were at a slightly higher risk of being admitted to the neonatal intensive care unit (NICU) than infants who whose mothers did not take any medication or had stopped their medications before or during pregnancy. This increase was caused by central nervous system disorders. The higher risk of admission was not affected by the stimulant medications used during pregnancy.
Women who were taking stimulant ADHD medication during pregnancy were also at an increased risk of having a caesarean delivery or having a baby born with an low Apgar score (less than 7). These increases did not appear to be affected by the kind of medication used during pregnancy.
The research suggests that the risk of a small amount with the use of ADHD medications during early pregnancy may be offset by the higher benefit for both mother and child of continued treatment for the woman's disorder. Doctors should discuss with their patients about this and, if possible, help them improve coping skills which may reduce the impact of her disorder in her daily functioning and her relationships.
Medication Interactions
Many doctors are confronted with the dilemma of whether to continue treatment or stop during pregnancy as more women are diagnosed with ADHD. The majority of these decisions are made in the absence of solid and reliable evidence either way, so physicians have to weigh their experience from their own experiences, those of other doctors, and what the research says on the topic, along with their own judgments for each individual patient.
The issue of possible risks to the infant can be difficult to determine. The research that has been conducted on this topic is based on observations rather than controlled studies and the results are contradictory. Most studies limit their analysis to live births, which can underestimate the severity of teratogenic effects that can lead to terminations or abortions of pregnancy. The study discussed in this journal club addresses these issues by analyzing data on live and deceased births.
The conclusion: While certain studies have demonstrated a positive association between ADHD medications and the possibility of certain birth defects, others have found no such relationship, and most studies demonstrate a neutral or slightly negative effect. As a result an accurate risk-benefit analysis is required in every case.
It isn't easy, but not impossible, for women with ADHD to stop taking their medication. In a recent article in the Archives of Women's Mental Health psychologist Jennifer Russell notes that stopping ADHD medication during pregnancy can lead to increased depression, feelings of loneliness, and family conflict for these patients. A loss of medication may affect the ability to safely drive and perform work-related tasks, which are crucial aspects of daily life for people with ADHD.
She suggests that women who are not sure whether to continue taking medication or stop due to pregnancy, educate their family members, coworkers, and acquaintances about the condition, the impact on daily functioning and the benefits of keeping the current treatment. It can also help the woman feel supported in her struggle with her decision. It is important to remember that some medications are able to be absorbed through the placenta therefore, if a patient decides to stop her ADHD medication during pregnancy and breastfeeding, she must be aware that traces of the medication could be transferred to the child.
Birth Defects Risk
As the use and abuse of ADHD drugs to treat symptoms of attention deficit hyperactivity disorder (ADHD) increases, so does concern about the potential adverse effects of the drugs on fetuses. A study that was published in the journal Molecular Psychiatry adds to the existing information on this topic. Researchers utilized two massive data sets to examine over 4.3 million pregnancies and determine if the use of stimulant medications increased the risk of birth defects. Although the risk overall remains low, the researchers found that exposure in the first trimester to ADHD medications was linked to a slightly higher rate of certain heart defects like ventriculo-septal defects (VSD).
The researchers of the study didn't discover any link between early use of medication and other congenital anomalies, such as facial deformities or club feet. The results are in line with previous studies that have shown a small, but significant increase in the number of cardiac malformations among women who started taking ADHD medication before the birth of their child. The risk grew in the latter half of pregnancy, as many women begin to discontinue their ADHD medications.
Women who used ADHD medication in the first trimester of pregnancy were also more likely to have caesarean sections, a low Apgar score after delivery and a baby who needed breathing assistance during birth. The authors of the study were not able to eliminate selection bias because they limited the study to women without other medical conditions that might have contributed to the findings.
Researchers hope their research will inform physicians when they meet pregnant women. The researchers recommend that while discussing the risks and benefits are crucial, the decision regarding whether or not to stop medication should be based on the severity of each woman's ADHD symptoms and her needs.
The authors warn that, although stopping the medication is a possibility to look into, it is not advised due to the high rate depression and mental health issues for women who are pregnant or who have recently given birth. Further, the research suggests that women who decide to stop their medications are more likely to have difficulties adapting to life without them following the baby's arrival.
Nursing
It can be a stressful experience to become a mother. Women with ADHD who have to deal with their symptoms while attending physician appointments and preparing for the arrival of a child and adjusting to new household routines can experience severe challenges. Therefore, many women decide to continue taking their ADHD medications throughout pregnancy.
The risk to a breastfeeding infant is not too high since the majority of stimulant medication passes through breast milk in low amounts. The rate of exposure to medication will differ based on dosage the medication is administered, its frequency and the time of day. Additionally, individual medications enter the infant's system differently through the gastrointestinal tract as well as breast milk, and the effect of this on a newborn infant is not fully known.
Some physicians may discontinue stimulant medication during a woman's pregnancy due to the absence of research. This is a difficult decision for the patient, who must balance the benefit of continuing her medication against the possible risks to the fetus. Until more information is available, doctors should inquire with all pregnant patients about their experience with ADHD and if they plan or are taking to take medication during the perinatal time.
A growing number of studies have revealed that most women can safely continue to take their ADHD medication while they are pregnant and nursing. In the end, many patients are choosing to do so, and in consultation with their doctor they have found that the benefits of continuing their current medication far outweigh any potential risks.
Women with ADHD who are planning to breastfeed should seek advice from a specialist psychiatrist prior to becoming pregnant. They should discuss their medication with their prescriber as well as the pros and cons of continuing treatment. This includes Non Stimulant Adhd Medication List-pharmacological strategies. Psychoeducation is also necessary to help pregnant women suffering from ADHD be aware of the symptoms and the underlying disorder. They should also be informed about treatment options and strengthen coping mechanisms. This should be a multidisciplinary approach with the GPs, obstetricians, and psychiatry. Pregnancy counselling should include discussion of a management plan for both the mother as well as the child, monitoring for signs of deterioration and the need for adjustments to the medication regimen.