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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are usually characterized by a focus on the practical aspects of study design, including recruitment and consent, adherence, and the use of routinely available equipment.

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A practical trial that employs various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is essential for practical trials to be valid and helps reduce bias in the results. However too much heterogeneity could cause issues with the design of the trial.

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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are typically requested by practitioners and policymakers to guide their decisions. They are also a good method to determine the causal relationship between an intervention and its outcomes. They should, however, not be used to replace explanation studies.

The concept of pragmatism is controversial and there are concerns regarding whether pragmatic trials could be used to replace explanation tests or if they should be an addition to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, 프라그마틱 슬롯 조작 which prove a physiological or 프라그마틱 슬롯 (simply click the next site) clinical hypothesis, and pragmatic trials, which guide policy and practice decisions. They also proposed the framework for pragmatic trials, which they called PRECIS.2 This tool sought to define the characteristics of a practical trial which includes the recruitment process, the design and implementation of the intervention, as well as monitoring.

There is a positive increase in the number pragmatic trials that have been published. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs) produced 34 articles, shown in red in Figure 2. This indicates that the health science community is becoming increasingly sensitized to the issue of pragmatism. It is important to note that the majority of these studies were conducted in primary-care settings.