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Pragmatic trials are studies designed to inform the practice of clinical trials in real life. They are typically focused on the practical aspects of study design, including the recruitment and consent process as well as adherence to the use of commonly available equipment.

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A pragmatic trial that uses a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is vital for pragmatic trials to be reliable and reduce bias in results, is also necessary. However too much heterogeneity could lead to problems with the design of the trial.

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The goal of pragmatic trials is to replicate real-life scenarios and gain maximum validity externally. They are usually commissioned by practitioners and policy makers to inform their decision making. They can also be used to assess the cause-effect relationship of an intervention and its results. However, they shouldn't be used in lieu for explanatory studies.

The idea of pragmatism is controversial and there are doubts about whether pragmatic trials should be used to replace explanation tests or if they should serve as an addition to them. Schwartz and Lellouch1 suggested an distinction between explanation-based studies, which support the validity of a physiological or clinical hypothesis, as well as pragmatic trials that aid in policy and practice decision-making. They also suggested a framework known as PRECIS for 프라그마틱 슬롯버프 pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic research study that includes recruitment, design, 프라그마틱 무료체험 메타 delivery of the intervention, and follow-up.

There is a growing increase in the number of pragmatic trials that have been published. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to remember that the majority of these studies were conducted in primary care settings.